GSK-3BETA INHIBITOR XII

Product Name: GSK-3BETA INHIBITOR XII
CAS No.: 601514-19-6
Chemical Name: GSK-3BETA INHIBITOR XII
Synonyms: TWS11;TWS S;CS-445;TWS119;CS-1924;TWS119, >=98%;TWS-119; TWS 119;OTAVA-BB 7070707013;GSK-3BETA INHIBITOR XII;GSK-3β Inhibitor, TWS119
CBNumber: CB2803764
Molecular Formula: C18H14N4O2
Formula Weight: 318.33
MOL File: 601514-19-6.mol

More

Less

GSK-3BETA INHIBITOR XII Property

Melting point:: 249 °C
Density: 1.42
storage temp.: 2-8°C
solubility: insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
pka: 8.99±0.10(Predicted)
form: powder
color: white to beige

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 361554
Product name: GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem
Packaging: 1mg
Price: $172
Updated: 2024/03/01

Sigma-Aldrich

Product number: 361554
Product name: GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem
Packaging: 5mg
Price: $532
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1271
Product name: TWS119
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $115
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1271
Product name: TWS119
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $451
Updated: 2023/06/20

Cayman Chemical

Product number: 10011251
Product name: TWS119
Purity: ≥90%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

More

Less

GSK-3BETA INHIBITOR XII Chemical Properties,Usage,Production

Uses

TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.

Uses

Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.

Definition

ChEBI: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol is a member of pyrroles.

General Description

A cell-permeable and potent inhibitor of GSK-3β (IC₅₀ = 30 nM). Binds to GSK-3β with high-affinity (K_d = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM).

Biological Activity

Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).

Biochem/physiol Actions

TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.

target

GSK-3β

storage

Store at +4°C

References

[1] ding s, wu t y h, brinker a, et al. synthetic small molecules that control stem cell fate. proceedings of the national academy of sciences, 2003, 100(13): 7632-7637.
[2] wu t y h, ding s. applying chemical tools to the discovery of novel regenerative medicine. drug discovery today: technologies, 2006, 3(3): 255-260.

GSK-3BETA INHIBITOR XII Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GSK-3BETA INHIBITOR XII Suppliers

Canada 1 China 106 China Hong Kong 1 India 2 Japan 1 United Kingdom 2 United States 19 Global 132

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

More

Less

View Lastest Price from GSK-3BETA INHIBITOR XII manufacturers

Career Henan Chemical Co

Product: GSK-3BETA INHIBITOR XII 601514-19-6
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

601514-19-6, GSK-3BETA INHIBITOR XIIRelated Search:

IWR-1-endo xav-939 U0126-EtOH 2,6-PYRIDINEDIAMINE, N6-[2-[[4-(2,4-DICHLOROPHENYL)-5-(1H-IMIDAZOL-1-YL)-2-PYRIMIDINYL]AMINO]ETHYL]-3-NITRO- Tideglusib CHIR-99021 1H-Pyrrolo[2,3-d]pyrimidine, 4-methoxy- (8CI,9CI) GSK-3BETA INHIBITOR XII

TWS119

GSK-3BETA INHIBITOR XII

3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL

CS-1924

TWS-119; TWS 119

CS-445

OTAVA-BB 7070707013

3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate

3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119

TWS 119 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol

GSK-3β Inhibitor, TWS119

TWS119, >=98%

TWS11

GSK-3β Inhibitor XII, TWS119

TWS 119 (This product is unavailable in the U.S.)

TWS S

Phenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-

GSK-3BETA INHIBITOR XII USP/EP/BP

601514-19-6

C18H14N4O22CF3CO2H

Akt

mTOR

PI3K

Inhibitors